

In humans, the early phase of motor skill acquisition is accompanied by a transient increase in corticospinal excitability (CSE). The corticospinal tract plays a key role in motor control 2, and plastic changes in the corticospinal pathway are important mechanisms for the acquisition of skilled movement 3. using brain stimulation and neuroimaging techniques (see 1 for review of early, seminal papers). In humans, neuroplasticity is commonly investigated indirectly e.g. Behavioural plasticity, as observed in motor skill learning, is contingent on underlying adaptations in the central nervous system, i.e. Throughout our lifespan, numerous motor skills have to be acquired and retained in memory. These findings underline the importance of continuously challenging patients and athletes to promote neural plasticity, skilled performance, and recovery. We demonstrate that progressive practice enhances motor skill learning and promotes corticospinal plasticity. Differences were maintained 8 days later, whereas both groups demonstrated equal retention 14 months later. Compared to constant practice, progressive practice resulted in a two-fold greater performance at an advanced task level and associated increases in corticospinal excitability.

continuously adjusted to their individual skill level. One group trained with constant task difficulty, while the other group trained with progressively increasing task difficulty, i.e. Two groups of participants practiced a visuomotor task requiring precise control of the right digiti minimi for 6 weeks. Here we investigate behavioural and electrophysiological effects of individually tailored progressive practice during long-term motor skill training. However, behavioural determinants leading to long lasting corticospinal plasticity and motor expertise remain unexplored. Motor skill acquisition depends on central nervous plasticity.
